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林桃燕博士在Organic Letters上发表论文

来源: 发布时间:2024-09-05 16:17:52 浏览次数: 【字体:

题目:Copper-Catalyzed Dual Remote Asymmetric Vinylogous Alkynylallylic Substitution of Yne-Allylic Esters with Coumarins

作者: Xin-Ru Wang, Meng-Die Li, Zi-Han Wang, Hui Zhu, Jia-Run Wang, Ying-Ying Wei, and Tao-Yan Lin*

单位:Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, School of Chemistry and Materials Science, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China

摘要:Chiral coumarins and their derivatives are ubiquitous structural motifs found in an array of biologically and therapeutically active natural products and drugs. Herein, a highly enantioselective dual remote copper-catalyzed vinylogous alkynylallylic substitution of yne-allylic esters with coumarins has been developed. The practicality of this method is exempliffed by the use of readily available starting materials; mild reaction conditions; excellent regio-, enantio-, and stereoselectivities; and the very broad substrate scope (67 examples), while the scalability and further applications of this method are illustrated by the gram-scale reaction and the series of derivations of the products.

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影响因子:4.9

分区情况:一区

链接https://doi.org/ 10.1021/acs.orglett.4c02199

                       (文、图:林桃燕 / 审核:李洪基 / 审校:韩满意 / 终审:韩满意)

终审:绿色和精准合成化学及应用教育部重点实验室
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