李洪基教授、黄强博士在Organic Letters上发表科研论文
题目:Tuning Regioselectivity in the [3+2] Cycloaddition of Alkynyl Sulfonium Salts with Binucleophilic N-Aryl Amidines
作者:Zhi Li, Zhengjun He, Qiang Huang*, Mei Kan, Hongji Li*
单位:Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, School of Chemistry and Materials Science, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China
摘要:A tunable reaction manifold of alkynyl sulfonium salts with binucleophilic N-aryl amidines in the absence of any transition metal catalyst is first reported. This methodology involves sequential addition/cyclization that is perfectly tuned by stepwise addition of K2CO3, affording a plethora of valuable 1,2,4- and 1,2,5-trisubstituted imidazoles in good yields with high regioselectivity. Importantly, trapping and isolation of the reactive intermediate unveiled the reaction mechanism of β-attack on the triple bond in this [3+2] cycloaddition reaction.
影响因子:5.2
分区情况:一区
链接:https://doi.org/10.1021/acs.orglett.4c01534
(文:黄强 / 审核:李洪基 / 审校:韩满意 / 终审:韩满意)
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